The easiest way to do this is multiply by 1, but if it is a (n)varchar data type, it is a little more challenging.

This was the query I had to run:

DECLARE @insurancenumber nvarchar(100),@charactertopurge nvarchar(1)
SET @charactertopurge='0'
SET @insurancenumber='00PK102947'
from Patient.dbo.PatientAlias
where AliasField=substring(@insurancenumber, patindex('%[^'+@charactertopurge+']%',@insurancenumber), len(@insurancenumber))

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